Aromatic keto-acids and their derivatives as inhibitors of...

Details Aromatic keto-acids and their derivatives as inhibitors of... Aromatic keto-acids and their derivatives as inhibitors of...

C - Chemistry, Metallurgy

07

D

C07D 295/155 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) C07D 211/14 (2006.01) C07D 211/18 (2006.01)

Patent

CA 2236096

Aromatic keto-acid compounds of formula (I) and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase) and stromelysin-1 and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurism, heart failure, restenosis, periodontal disease, corneal ulceration, treatment of burns, decubital ulcers, wound healing, cancer, arthritis, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes. Ar, Y, W, R1-R4, n are as defined in the application.

Cette invention se rapporte à des composés céto-acides aromatiques, représentés par la formule (I), à des dérivés de ces composés, à des procédés pour la préparation de ces composés et à des compositions pharmaceutiques contenant ces composés, lesquels sont utiles comme inhibiteurs des métalloprotéinases matricielles, en particulier la gélatinase A (gélatinase de 72 kD) et la stromélysine-1, et dans le traitement de troubles, tels que la sclérose en plaques, la rupture de la plaque athéroscléreuse, les anévrismes aortiques, les défaillances cardiaques, la resténose, les maladies du périodonte, les ulcérations de la cornée, les brûlures, les ulcères de décubitus, la cicatrisation, le cancer, l'arthrite ou d'autres maladies auto-immunes ou inflammatoires qui dépendent de l'invasion des tissus par les leucocytes. Ar, Y, W, R?1¿-R?4¿ et n sont définis dans les pièces descriptives de l'invention.

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