Aromatic ketones

Details Aromatic ketones Aromatic ketones

C - Chemistry, Metallurgy

07

C

260/644.1, 260/6

C07C 33/18 (2006.01) A61K 31/12 (2006.01) C07C 43/20 (2006.01) C07C 49/76 (2006.01)

Patent

CA 1049039

ABSTRACT OF THE DISCLOSURE Napthylene derivatives of the formula (II): Image (II) wherein X is a chlorine or bromine atom or methoxy, methylthio or alkyl group of 1-4 carbon atoms; Y is a -CHR1-CH(R2)-, CHR1-CO-, CHR1-C(CH)R2- or -C(R1) = C(R2)- group where R1 and R2 are each a hydrogen atom or a methyl, ethyl group or propyl group and Z is a R4, (CH2)nCOR4, (CH2)nCH(OH)R4, or (CH2)nC(CH3)(OH)R4 group where R4 is an alkyl group of 1 to 4 carbon atoms and n is 0, 1 or 2; with the proviso that Y - Z contains at least one oxygen atom and not more than one carbonyl group and X is not methoxy when Y - Z is a -CH2CH2COCH3 group. These derivatives have good anti-inflammatory activity while having an improved therapeutic ration as based on gastro-intestinal irritancy.

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