Aromatic nitrogen-containing 6-membered cyclic compounds

Details Aromatic nitrogen-containing 6-membered cyclic compounds Aromatic nitrogen-containing 6-membered cyclic compounds

C - Chemistry, Metallurgy

07

D

C07D 403/14 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61P 1/04 (2006.01) A61P 9/12 (2006.01) A61P 15/10 (2006.01) C07D 403/04 (2006.01) C07D 413/14 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2383466

The present invention is directed to an aromatic nitrogen-containing 6-membered cyclic compound of the formula (I): (see formula I) wherein Ring A is a substituted or unsubstituted nitrogen-containing heterocyclic group; R1 is a substituted or unsubstituted lower alkyl group, -NH-Q-R3 (R3 is a substituted or unsubstituted nitrogen containing heterocyclic group, and Q is a lower alkylene group or a single bond), or -NH-R4 (R4 is a substituted or unsubstituted cycloalkyl group); R2 is a substituted or unsubstituted aryl group; one of Y and Z is =CH-, and the other is =N-, or a pharmaceutically acceptable salt thereof. These compounds exhibit excellent selective PDE V inhibitory activities, and hence, are useful in the prophylaxis or treatment of penile erectile dysfunction, etc.

Composés cycliques aromatiques azotés à six éléments de formule générale (I) ou sels pharmaceutiquement acceptables desdits composés, qui exercent une excellente activité d'inhibition sélective contre PDE V et qui sont utiles en tant que médicaments prophylactiques ou thérapeutiques pour les troubles de l'érection ou analogues. Dans ladite formule, A est un groupe hétérocyclique azoté éventuellement substitué, R<1> est alkyle inférieur éventuellement substitué, -NH-Q-R<3> (dans laquelle R<3> est un groupe hétérocyclique azoté éventuellement substitué et Q est alkylène inférieur ou une liaison simple) ou -NH-R<4> (dans laquelle R<4> est cycloalkyle éventuellement substitué), R<2> est aryle éventuellement substitué et Y et Z sont l'un =CH- et l'autre =N-.

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