Aromatic phosphonates as protein tyrosine phosphatase 1b...

C - Chemistry – Metallurgy – 07 – F

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C07F 9/38 (2006.01) A61K 31/66 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2393359

The invention encompasses the novel class of compounds represented by formula (I), which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related diseases.

La présente invention concerne une nouvelle classe de composés représentés par la formule (I). Ces composés sont des inhibiteurs de l'enzyme PTP-1B. La présente invention traite également de compositions et de procédés pharmaceutiques permettant de traiter ou de prévenir des maladies induites par PTP-1B, parmi lesquelles le diabète, l'obésité et les maladies liées au diabète.

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