C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) C12N 9/10 (2006.01) C12N 15/00 (2006.01) C12N 15/63 (2006.01) C12P 7/22 (2006.01) C12P 7/26 (2006.01)
Patent
CA 2718469
Nucleic acid molecules from hop has been isolated and characterized and encode polypeptides having aromatic prenyltransferase activity. Expression or over--expression of the nucleic acids alters levels of terpenophenolic compounds. The polypeptides may be used in vivo or in vitro to produce terpenophenolic compounds (e.g. prenylated acylphloroglucinols and prenylflavonoids) such as prenyl-PIVP, prenyl-PIPB, humulone, lupulone, desmethylxanthohumol and xanthohumol.
Cette invention concerne des molécules d'acides nucléiques issues du houblon (Humulus lupulus) qui ont été isolées et caractérisées, lesdites molécules d'acides nucléiques codant pour des polypeptides ayant une activité prényltransférase aromatique. L'expression ou la surexpression desdites molécules d'acides nucléiques modifie le taux de composés terpéno- phénoliques. Les polypeptides peuvent être utilisés in vivo ou in vitro pour produire des composés terpénophénoliques (par exemple, acylphloroglucmols prénylés et prénylflavonoïdes) tels que prényl-PIVP, prényl-PIBP, humulone, lupulone, desméthylxanthohumol et xanthohumol.
Liu Enwu
Nagel Jana
Page Jonathan E.
Eckenswiller Laura Catherine
National Research Council Of Canada
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