C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/66 (2006.01) A61K 31/445 (2006.01) A61K 31/4523 (2006.01) A61P 9/00 (2006.01) C07D 309/08 (2006.01) C07D 335/02 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2372934
A treatment process is disclosed that comprises administering an effective amount of an aromatic sulfone hydroxamic acid that exhibits excellent inhibitory activity of one or more matrix metalloprotease (MMP) enzymes, such as MMP-2, MMP-9 and MMP-13, while exhibiting substantially less inhibition at least of MMP-1 to a host having a condition associated with pathological matrix metalloprotease activity. Also disclosed are metalloprotease inhibitor compounds having those selective activities, processes for manufacture of such compounds and pharmaceutical compositions using an inhibitor. A contemplated compound corresponds in structure to formula (B).
L'invention concerne un procédé de traitement consistant à administrer une dose efficace d'un acide hydroxamique à sulfone aromatique présentant une excellente activité inhibitrice d'une ou de plusieurs enzymes métalloprotéases matricielles (MMP), telles que MMP-2, MMP-9 et MMP-13, tout en présentant sensiblement moins d'inhibition au moins de MMP-1 sur un hôte présentant un état associé à l'activité de la métalloprotéase matricielle pathologique. L'invention concerne également des composés inhibiteurs de métalloprotéase présentant ces activités sélectives, des procédés de production de ces composés et des compositions pharmaceutiques utilisant un inhibiteur. Un composé de l'invention correspond de par sa structure à la formule B.
Barta Thomas E.
Becker Daniel P.
Bedell Louis J.
Boehm Terri L.
Carroll Jeffrey N.
Osler Hoskin & Harcourt Llp
Pharmacia Corporation
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