Aromatic sulfone hydroxamic acids and their use as protease...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 309/08 (2006.01) A61K 31/351 (2006.01) A61K 31/41 (2006.01) A61K 31/4465 (2006.01) A61K 31/453 (2006.01) A61K 31/454 (2006.01) A61P 25/00 (2006.01) C07D 211/06 (2006.01) C07D 211/66 (2006.01) C07D 309/12 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 491/04 (2006.01)

Patent

CA 2504737

This invention is directed to aromatic sulfone hydroxamic acids (including aromatic sulfone hydroxamates) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as "matrix metalloprotease" or "MMP") activity and/or aggrecanase activity. This invention also is directed to a prevention or treatment method that comprises administering such a compound or salt in an MMP-inhibiting and/or aggrecanase-inhibiting effective amount to an animal, particularly a mammal having (or disposed to having) a pathological condition associated with MMP and/or aggrecanase activity.

Cette invention concerne des acides hydroxamiques sulfoniques aromatiques (y compris des hydroxamates sulfoniques aromatiques) et leurs sels, qui, entre autres, inhibent l'activité de la métalloprotéinase matricielle (également connue sous le nom de "métalloprotéase matricielle" ou "MMP") et/ou l'activité de l'aggrécanase. L'invention concerne également une méthode de prévention ou de traitement, qui consiste à administrer une quantité du composé ou de son sel propre à inhiber l'activité de la MMP et/ou de l'aggrécanase, à un animal, en particulier un mammifère, présentant une affection pathologique (ou une prédisposition à ladite affection pathologique) associée à l'activité de la MMP et/ou de l'aggrécanase.

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