Aromatic sulfone hydroxamic acids and their use as protease...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 405/12 (2006.01) C07D 211/66 (2006.01) C07D 335/02 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/06 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2467565

This invention is directed to aromatic sulfone hydroxamates (also known as aromatic sulfone hydroxamic acids) and salts thereof that, inter alia, tend to inhibit matrix metalloproteinase (also known as matrix metalloprotease or MMP) activity and/or aggrecanase activity. This invention also is directed to a treatment method that comprises administering such a compound or salt in an MMP-inhibiting and/or aggrecanase-inhibiting effective amount to an animal, particularly a mammal having (or disposed to having) a pathological condition associated with MMP activity and/or aggrecanase activity.

L'invention concerne des hydroxamates de sulfones aromatiques (connus aussi sous la dénomination acides hydroxamiques de sulfones aromatiques) ainsi que leurs sels qui, entre autre, tendent à inhiber l'activité de métalloprotéinase de matrice (connue aussi sous la dénomination métalloprotéase de matrice ou MMP) et/ou l'activité d'aggrécanase. L'invention concerne aussi une méthode de traitement consistant à administrer un tel composé ou un de ses sels dans une quantité efficace d'inhibition de l'activité MMP et/ou aggrécanase à un animal, en particulier à un mammifère atteint (ou disposé à être atteint) d'un trouble pathologique associé à une activité MMP et/ou aggrécanase.

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