C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/02 (2006.01) C07C 317/44 (2006.01) C07D 209/00 (2006.01) C07D 211/04 (2006.01) C07D 213/14 (2006.01) C07D 213/30 (2006.01) C07D 213/82 (2006.01) C07D 215/02 (2006.01) C07D 217/02 (2006.01) C07D 231/10 (2006.01) C07D 235/04 (2006.01) C07D 239/20 (2006.01) C07D 261/02 (2006.01) C07D 263/06 (2006.01) C07D 273/01 (2006.01) C07D 277/20 (2006.01) C07D 279/06 (2006.01) C07D 279/12 (2006.01) C07D 307/34 (2006.01) C07D 333/06 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 4
Patent
CA 2283145
An aromatic sulfonyl alpha-hydroxy hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed, as is a treatment process that comprises administering a contemplated aromatic sulfonyl alpha- hydroxy hydroxamic acid compound in a MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.
La présente invention concerne un composé aromatique d'acide sulfonyl alpha-hydroxy hydroxamique qui inhibe notamment une activité de métalloprotéase matricielle (MMP). La présente invention concerne également un procédé de traitement qui consiste à administrer le composé aromatique d'acide sulfonyle alpha-hydroxy hydroxamique en question, à raison d'une quantité efficace destinée à inhiber l'activité d'un enzyme MMP, à un hôte présentant un état associé à l'activité pathologique de métalloprotéase matricielle.
Boehm Terri L.
Decrescenzo Gary A.
Freskos John N.
Heintz Robert M.
Howard Susan C.
Monsanto Company
Osler Hoskin & Harcourt Llp
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