C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 237/22 (2006.01) A61K 31/165 (2006.01) A61K 31/395 (2006.01) C07C 237/08 (2006.01) C07C 237/36 (2006.01) C07C 237/42 (2006.01) C07D 209/42 (2006.01) C07D 211/32 (2006.01) C07D 211/46 (2006.01) C07D 211/62 (2006.01) C07D 213/81 (2006.01) C07D 213/82 (2006.01) C07D 257/04 (2006.01) C07D 263/04 (2006.01) C07D 295/092 (2006.01) C07D 295/15 (2006.01) C07D 295/185 (2006.01) C07D 307/32 (2006.01) C07D 401/04 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2164571
Compounds of formula I Image (I), wherein R1 is a 2-RA-3-RB-phenyl radical, a 2-RA-4-RC-phenyl radical, a 2-RA-pyridin-3-yl radical, a 3-RA-pyridin-2-yl radical or a 1-RD-indol-3-yl radical, wherein one of the radicals RA and RB is an aliphatic or heterocycloaliphatic-aliphatic radical or free or aliphatically, araliphatically or heteroaraliphatically etherified hydroxy and the other is hydrogen, an aliphatic radical or free or esterified or amidated carboxy, RC is hydrogen, an aliphatic radical, free or aliphatically, araliphatically, heteroaraliphatically or heteroarylaliphatically etherified hydroxy or an unsubstituted or heteroaliphatically substituted amino group, and RD is an aliphatic, araliphatic or heteroaliphatic radical, one of the radicals X1 and X2 is carbonyl and the other is methylene, R2 is an aliphatic radical, R3 is unsubstituted or aliphatically substituted amino, R4 is an aliphatic or araliphatic radical, and R5 is an aliphatic or cycloaliphatic- aliphatic radical or an optionally hydrogenated and/or oxo-substituted heteroaryl radical or an optionally hydrogenated and/or oxo-substituted heteroaryl or heteroaliphatyl radical bonded via a carbon atom, and the salts thereof, have renin-inhibiting properties and can be used as antihypertensive active ingredients of medicaments.
Cohen Nissim Claude
Goschke Richard
Herold Peter
Maibaum Jurgen Klaus
Rigollier Pascal
Fetherstonhaugh & Co.
Novartis Ag
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