Aroyl amino acids

Details Aroyl amino acids Aroyl amino acids

C - Chemistry, Metallurgy

07

C

260/295, 260/329

C07C 69/84 (2006.01) A61K 31/195 (2006.01) C07C 63/04 (2006.01) C07D 207/16 (2006.01) C07D 213/75 (2006.01) C07D 215/38 (2006.01) C07D 295/08 (2006.01) C07D 307/52 (2006.01) C07D 307/70 (2006.01) C07D 333/36 (2006.01) A61K 31/22 (2006.01)

Patent

CA 1191139

ABSTRACT OF THE INVENTION Compounds of the structure Image wherein: Q is oxygen, sulfur or NH X and Y are hydrogen, halogen, hydroxy, alkoxy, trifluoromethyl, nitro, carboxy, cyano, sulfonamido, sul- fhydryl, alkyl, alkenyl, alkynyl, alkanoyl, alkylmercapto, amino, alkylamino, dialkylamino, alkylsulfinyl, and alkylsul- fonyl and may be the same or different; R1 is hydrogen, alkanoyl, substituted alkanoyl wherein the substituent is hydroxy, amino or cycloalkyl, aroyl, arylalkanoyl, or cycloalkylcarbonyl, n is an integer from 1 to 4 inclusive, R2 and R3 are hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, aryl, aralkyl, and substituted derivatives thereof wherein the substituents are hydroxy, amino, alkylamino, dialkylamino, alkoxy, halogen, hydroxy, mercapto, alkylmercapto and nitro, and may be the same or different, M is alkyl, alkenyi, alkynyl, cycloalkyl, cyclo- alkylalkyl, aryl, aralkyl, and hertero; and Z is hydroxy, amino, alkylamino, dialkylamino, or alkoxy, have angiotensin converting enzyme inhibitory activity.

392790

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