C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/245, 260/352
C07D 307/80 (2006.01) C07C 45/68 (2006.01) C07D 307/79 (2006.01) C07D 307/83 (2006.01) C07D 333/54 (2006.01) C07D 333/60 (2006.01) C07D 407/00 (2006.01) C07D 407/12 (2006.01) C07D 409/06 (2006.01)
Patent
CA 1241008
ABSTRACT OF THE DISCLOSURE: Novel aroyl-substituted benzofuran and benzothiophene acetic and proprionic acids are disclosed herein having the formula Image (I) or a pharmaceutically acceptable salt thereof, and the individual (1) and (d) isomers of the propionic acid or propionate compounds, wherein R1 is hydrogen, hydroxy, lower alkoxy or methyl; R2 is hydrogen or methyl; R3 is hydrogen, alkyl, phenyl, phenyl lower alkyl, 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, Image wherein the R groups are the same and are lower alkyl; X1 is oxygen or is sulfur if R1 is hydrogen; X2 is oxygen or sulfur; Ar is phenyl unsubstituted or independently substituted with one or more substituents which are lower alkyl, lower alkoxy, halo, lower alkylsulfinyl, lower alkylsulfonyl, lower alkylthio, 2-furyl, 3-furyl, 2-thienyl, or 3-thienyl; and the dotted line represents a single or double bond. These compounds are useful as analgesic, anti-inflammatory, and antipyretic agents.
458906
Johnson Douglas S. Q.c.
Syntex (u.s.a.) Llc
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