Aroyl substituted dihydro-1,4-thiazines

Details Aroyl substituted dihydro-1,4-thiazines Aroyl substituted dihydro-1,4-thiazines

C - Chemistry, Metallurgy

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C07D 279/12 (2006.01) A61K 31/54 (2006.01) C07C 45/63 (2006.01) C07C 49/80 (2006.01) C07C 323/25 (2006.01) C07D 209/48 (2006.01) C07D 417/00 (2006.01) C07D 417/06 (2006.01)

Patent

CA 1279870

Aroyl substituted dihydro-1,4-thiazines Abstract Compounds of the formula I, Image I wherein Ar is pyridyl, phenyl or phenyl substituted by halogen, halo-C1-4-alkyl, C1-4-alkoxy or carboxy-C1-4- alkyl, n is zero, one or two,R1 is hydrogen, C1-4-alkyl, heterocyclyl-C2 4-alkyl, amino-C2-4-alkyl, C1-4-alkyl- amino C2-4 alkyl, di2C1-4 alkylamino-C2-4 alkyl or C1-4-alkanoyl, and R2 is hydrogen, carboxy-C1-4-alkyl or C1-4-alkoxy-carbonyl-C1-4-alkyl are disclosed as well as their preparation, pharmaceutical compositions containing the same and the use thereof as antirheumatic agents.

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