Aroyl urea and carbamic acid derivatives

Details Aroyl urea and carbamic acid derivatives Aroyl urea and carbamic acid derivatives

C - Chemistry, Metallurgy

07

D

167/228, 260/272

C07D 451/06 (2006.01) A61K 31/435 (2006.01) C07D 231/04 (2006.01) C07D 451/04 (2006.01) C07D 451/10 (2006.01) C07D 453/02 (2006.01)

Patent

CA 1334095

Aryl or aroyl ureas and carbamic acid derivatives of formula A-X-NHCW-Y-B and pharmaceutically acceptable salts thereof wherein A is a specified aromatic radical including optionally substituted phenyl X is a direct bond or CO W is O or S Y is NH or S and B is a specified saturated azacyclic ring, eg tropan-3-yl or quinuclidin-3-yl, possess 5-HT3-antagonistic activity and are, for example, useful in treatment of migraine, emesis, anxiety, gastro-intestinal disorders and as anti-psychotics.

585519

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