Aroylethenylpiperidinobutyrophenone antipsychotic agents

Details Aroylethenylpiperidinobutyrophenone antipsychotic agents Aroylethenylpiperidinobutyrophenone antipsychotic agents

C - Chemistry, Metallurgy

07

D

260/292.2

C07D 211/32 (2006.01) C07D 405/06 (2006.01)

Patent

CA 1147735

M-1042 ABSTRACT OF THE DISCLOSURE 4-Aroylethenyl-1-piperidinobutyrophenone derivatives and pharmaceutically acceptable salts thereof of the following general structure: Image wherein R is hydrogen, alkyl, alkoxy, halogen or trifluoromethyl; and R' is hydrogen or halogen, are useful as antipsychotic agents. The novel compounds are produced by aldol condensation of an acetophenone with a protected 4-(4-formyl-1-piperidino)-butyrophenone.

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