Aroylfuranes and aroylthiophenes

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 307/79 (2006.01) A61K 31/34 (2006.01) A61K 31/435 (2006.01) A61P 35/00 (2006.01) C07D 307/82 (2006.01) C07D 493/04 (2006.01)

Patent

CA 2545821

The invention relates to compounds of formula (I) and of formula (II) wherein ring A is a phenyl, pyridine, pyrimidine or pyrazine ring, W and X are carbon or nitrogen, Y is oxygen or sulfur, R0 is different from hydrogen, Rx is - (C=O)R1 or cyano; R1 is hydrogen, optionally substituted hydroxy or optionally substituted amino, and the other substituents are as described in the specification. The invention further relates to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I) and of formula (II), to the use of compounds of formula (I) and of formula (II) for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using compounds of formula (I), of formula (II) or of pharmaceutical compositions containing same.

La présente invention a trait à des composés de formule (I) et de formule (II), dans lesquelles : le noyau A est un noyau phényle, pyridine, pyrimidine ou pyrazine ; W et X sont carbone ou azote ; Y est oxygène ou soufre ; R0 est autre qu'hydrogène ; Rx est -(C=O)R1 ou cyano; R1 est hydrogène, hydroxy éventuellement substitué ou amino éventuellement substitué, et les autres substituants sont tels que définis dans la description. L'invention a également trait à des procédés de synthèse de tels composés, à des compositions pharmaceutiques contenant des composés de formule (I) et de formule (II), à l'utilisation des composés de formule (I) et de formule (II) pour la préparation d'une composition pharmaceutique pour le traitement de maladies néoplasiques et autoimmunes, et à des procédés pour le traitement de maladies néoplasiques et autoimmunes mettant en oeuvre des composés de formule (I), de formule (II) ou des compositions pharmaceutiques en contenant.

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