Arpe-19 as a platform cell line for encapsulated cell-based...

C - Chemistry – Metallurgy – 12 – N

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C12N 5/02 (2006.01) C12N 5/071 (2010.01) A61K 9/00 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) A61L 27/00 (2006.01) A61L 27/38 (2006.01) A61M 37/00 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) A61K 35/12 (2006.01) C12N 11/00 (2006.01)

Patent

CA 2365532

ARPE-19 cells were evaluated as a platform cell line for encapsulated and unencapsulated cell-based delivery technology. ARPE-19 cells were found to be hardy (the cell line is viable under stringent conditions, such as in central nervous system or intra-ocular environment); can be genetically modified to secrete the protein of choice; has a long life span; is of human origin; has goodin vivo device viability; delivers efficacious quantity of growth factor; triggers no or low level host immune reaction, and is non-tumorigenic.

On a étudié des cellules ARPE-19 en tant que lignée cellulaire plate-forme pour la technologie d'administration à base de cellules encapsulées et non encapsulées. On a constaté que les cellules ARPE-19 sont rustiques (la lignée cellulaire est viable dans des conditions strictes, telles que dans le système nerveux central ou l'environnement intra-oculaire); qu'elles peuvent être manipulées génétiquement, de sorte qu'elles sécrètent la protéine choisie; qu'elles présentent une longévité élevée; qu'elles sont d'origine humaine; qu'elles présentent une bonne viabilité in vivo dans les dispositifs; qu'elles libèrent une quantité efficace de facteur de croissance; qu'elles déclenchent une faible voire aucune réaction du greffon contre l'hôte et qu'elles sont non tumorigènes.

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