Arrays of protein-capture agents and methods of use thereof

G - Physics – 01 – N

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G01N 33/543 (2006.01) C07K 17/00 (2006.01) G01N 33/551 (2006.01)

Patent

CA 2337075

Arrays of protein-capture agents useful for the simultaneous detection of a plurality of proteins which are the expression products, or fragments thereof, of a cell or population of cells in an organism are provided. A variety of antibody arrays, in particular, are described. Methods of both making and using the arrays of protein-capture agents are also disclosed. The invention arrays are particularly useful for various proteomics applications including assessing patterns of protein expression and modification in cells.

L'invention concerne des groupements d'agents d'interception de protéine utiles pour mettre en oeuvre une détection simultanée de plusieurs protéines qui sont les produits d'expression, ou des fragments de ceux-ci, d'une cellule ou d'une population de cellules dans un organisme. Divers groupements d'anticorps sont notamment décrits. L'invention concerne également des procédés de fabrication et d'utilisation des groupements d'agents d'interception de protéine. Les groupements de l'invention sont particulièrement utiles pour diverses applications de protéomique, y compris pour évaluer des motifs d'expression et de modification de protéine dans des cellules.

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