Arrays of proteins and methods of use thereof

Details Arrays of proteins and methods of use thereof Arrays of proteins and methods of use thereof

G - Physics

01

N

G01N 33/543 (2006.01) G01N 33/551 (2006.01)

Patent

CA 2337654

Protein arrays for the parallel, in vitro screening of biomolecular activity are provided. Methods of using the protein arrays are also disclosed. On the arrays, a plurality of different proteins, such as different members of a single protein family, are immobilized on one or more organic thin films on the substrate surface. The protein arrays are particularly useful in drug development, proteomics, and clinical diagnostics.

L'invention concerne des groupements de protéines permettant de mettre en oeuvre un criblage in vitro en parallèle d'activité biomoléculaire. Des procédés d'utilisation des groupements de protéines sont également décrits. Dans les groupements, plusieurs protéines différentes telles que des membres différents d'une seule famille de protéines, sont immobilisées sur un ou plusieurs films minces organiques à la surface du substrat. Les groupements de protéines sont particulièrement utiles dans le développement de médicaments, la protéomique et le diagnostic clinique.

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