Arrays with cleavable linkers

G - Physics – 01 – N

Patent

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Details

G01N 33/53 (2006.01) A61K 31/702 (2006.01) C07H 3/06 (2006.01)

Patent

CA 2571431

The invention provides arrays of molecules where the molecules (e.g., glycans) are attached to the arrays by cleavable linkers. The invention also provides methods for using these arrays, methods for identifying the structural elements of molecules bound to these arrays by using the cleavable linkers, especially the structural elements that are important for binding to test samples. The invention further provides methods for evaluating whether test samples and test molecules can bind to distinct glycans on the arrays and useful glycans identified using the methods and arrays provided herein.

L'invention concerne des réseaux de molécules dans lesquels les molécules (par exemple, des glycanes) sont fixées aux réseaux au moyen de liants clivables. L'invention concerne également des procédés d'utilisation de ces réseaux, des procédés d'identification des éléments structurels de molécules liés à ces réseaux, au moyen des liants clivables, notamment les éléments structurels importants pour la liaison à des échantillons test. L'invention concerne, en outre, des procédés permettant d'évaluer si des échantillons test et des molécules test peuvent se lier à divers glycanes sur les réseaux et des glycanes utiles identifiés au moyen des procédés et des réseaux selon l'invention.

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