Artemin, a novel neurotrophic factor

Details Artemin, a novel neurotrophic factor Artemin, a novel neurotrophic factor

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12N 15/16 (2006.01) C12N 15/63 (2006.01) C12N 15/64 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2343927

A novel growth factor, artemin, which belongs to the GDNF/neurturin/persephin family of growth factors, is disclosed. The human and mouse amino sequences have been identified. Human and mouse artemin genomic DNA sequences have been cloned and sequenced and the respective cDNA sequences identified. In addition, methods for treating degenerative conditions using artemin, methods for detecting artemin gene alterations and methods for detecting and monitoring patient levels of artemin are provided.

L'invention concerne un nouveau facteur de croissance, l'artémine, qui appartient à la famille des facteurs de croissance GDNF/neurturine/perséphine. Les séquences amino humaines et murines ont été identifiées. Les séquences de l'ADN génomique de l'artémine humaine et murine ont été clonées et séquencées, et l'on a identifié les séquences d'ADNc respectives. L'invention concerne également des procédés relatifs au traitement des états dégénératifs par le biais de l'artémine, ainsi que des procédés relatifs à la détection des altérations du gène de l'artémine et des procédés relatifs à la détection et au contrôle des niveaux d'artémine chez les patients.

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