Arteries for use in heterologous transplants

Details Arteries for use in heterologous transplants Arteries for use in heterologous transplants

A - Human Necessities

61

L

3/121, 8/54

A61L 27/36 (2006.01) A61F 2/06 (2006.01)

Patent

CA 1076752

ABSTRACT OF THE DISCLOSURE The invention relates to a new process for the preparation of arteries for use in heterologous transplants which reduces immunological drawbacks and decreases the risk of contamination and/or infection. The process comprises obtaining a length of animal artery free from surrounding tissue, any collateral vessels being sealed off, removing muscle tissue and elastic fibres from the wall of the artery by proteolytic splitting whereby a solution containing a proteolytic enzyme at an appropriate pH is passed continuously through the artery and subjecting the collagen tube thereby produced to tanning by passing continuously therethrough a buffered cross- linking solution whereby the density and stability of the tube is increased.

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