A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/505 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2190750
9-methyl-3-(1H-tetrazol-5-yl) -4H-pyrido [1, 2-a] pyrimidin-4-one represented by the following formula; Image and the physiologically-acceptable salts thereof showed to have excellent inhibitory effect on the proliferation of vascular smooth muscle cells and are effective to prevent the occurrence of restenosis after the operation of PTCA, and hence the compounds can be useful for the therapeutic and preventive treatment for arteriosclerosis and other diseases whereto the proliferation of vascular smooth muscle cells is directly concerned.
L'invention concerne du 9-méthyl-3-(1H-tétrazol-5-yl)-4H-pyrido-[1,2-a]pyrimidine-4-one représenté par la formule (I) ou un sel physiologiquement acceptable de ce dernier, présentant un excellent pouvoir d'inhibition de la croissance des muscles lisses vasculaires, étant très efficace contre la resténose après l'angiographie coronarienne, et ayant un effet prophylactique ou thérapeutique contre les maladies dans lesquelles les muscles lisses vasculaires sont impliqués comme l'artériosclérose.
Kawashima Toshio
Moroi Masao
Ohsawa Hidefumi
Tomioka Hisao
Gowling Lafleur Henderson Llp
Mitsubishi-Tokyo Pharmaceuticals Inc.
Tokyo Tanabe Company Limited
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