Artery- and vein-specific proteins and uses therefor

Details Artery- and vein-specific proteins and uses therefor Artery- and vein-specific proteins and uses therefor

A - Human Necessities

61

K

A61K 38/17 (2006.01) C12N 5/071 (2010.01) A61K 35/12 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/09 (2006.01) C12Q 1/00 (2006.01) C12Q 1/04 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/567 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2325563

Arterial and venous endothelial cells are molecularly distinct from the earliest stages of angiogenesis. This distinction is revealed by expression on arterial cells of a transmembrane ligand, called EphrinB2 whose receptor EphB4 is expressed on venous cells. Targeted disruption of the EprhinB2 gene prevents the remodeling of veins from a capillary plexus into properly branched structures. Moreover, it also disrupts the remodeling of arteries, suggesting that reciprocal interactions between pre-specified arterial and venous endothelial cells are necessary for angiogenesis. This distinction can be used to advantage in methods to alter angiogenesis, methods to assess the effect of drugs on artery cells and vein cells, and methods to identify and isolate artery cells nad vein cells, for example.

Les cellules endothéliales artérielles et veineuses sont, en ce qui concerne leurs molécules, distinctes par rapport aux premières étapes de l'angiogenèse. Cette distinction est révélée par l'expression, sur des cellules artérielles, d'un ligand transmembranaire appelé EphrinB2, dont le récepteur EphB4 est exprimé sur des cellules veineuses. L'interruption ciblée du gène EphrinB2 empêche le remodelage de veines en structures convenablement ramifiées à partir d'un plexus capillaire. De plus, il interrompt le remodelage d'artères, donnant à penser que les interactions de cellules endothéliales artérielles et veineuses prédéterminées sont nécessaires pour l'angiogenèse. Cette distinction peut être utilisée avantageusement, par exemple, dans des procédés de modification de l'angiogenèse, dans des procédés évaluant l'effet de médicaments sur des cellules artérielles et des cellules veineuses, ou dans des procédés destinés à identifier et isoler des cellules artérielles et des cellules veineuses.

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