C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) C07K 14/51 (2006.01) C12N 15/861 (2006.01)
Patent
CA 2701215
The present invention relates to recombinant vectors expressing the BMP-7 polypeptide in host cells and to pharmaceutical compositions comprising such recombinant vectors. The invention also encompasses methods for prevention and/or treatment of osteoarthritis in mammals, advantageously in humans, dogs, horses and cats, by intraarticular administration of the recombinant vectors and pharmaceutical compositions of the invention.
L'invention concerne des vecteurs recombinés qui expriment le polypeptide BMP-7 dans des cellules hôtes, et des compositions pharmaceutiques comprenant ces vecteurs recombinés. L'invention concerne aussi des procédés visant à prévenir et/ou à traiter l'ostéoarthrite chez des mammifères, avantageusement chez l'être humain, le chien, le cheval et le chat, par l'administration intra-articulaire des vecteurs recombinés et des compositions pharmaceutiques de l'invention.
Merial Limited
Smart & Biggar
LandOfFree
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