C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/78 (2006.01) C07K 16/00 (2006.01) C12N 1/21 (2006.01) C12N 15/10 (2006.01) C12N 15/70 (2006.01) G01N 33/68 (2006.01) G01N 33/78 (2006.01)
Patent
CA 2293632
A fibronectin type III (Fn3) polypeptide monobody, a nucleic acid molecule encoding said monobody, and a variegated nucleic acid library encoding said monobody, are provided by the invention. Also provided are methods of preparing a Fn3 polypeptide monobody, and kits to perform said methods. Further provided is a method of identifiying the amino acid sequence of a polypeptide molecule capable of binding to a specific binding partner (SBP) so as to form a polypeptide:SSP complex, and a method of identifying the amino acid sequence of a polypeptide molecule capable of catalyzing a chemical reaction with a catalyzed rate constant, kcat, and an uncatalyzed rate constant, kuncat, such that the ratio of kcat/kuncat is greater than 10.
L'invention concerne un monocorps de polypeptide de fibronectine de type III (Fn3), une molécule d'acide nucléique codant ce monocorps, et une banque d'acide nucléique à panachure codant ce monocorps. L'invention concerne également des méthodes de préparation d'un monocorps de polypeptide de Fn3, ainsi que des trousses permettant de mettre en oeuvre ces méthodes. L'invention concerne en outre une méthode d'identification de la séquence d'acides aminés d'une molécule de polypeptide capable de se lier à un partenaire de liaison spécifique (SBP) pour former un complexe polypeptide: SSP et une méthode d'identification de la séquence d'acides aminés d'une molécule de polypeptide capable de catalyser une réaction chimique avec une constante de vitesse catalysée, k¿cat?, et une constante de vitesse non catalysée, k¿uncat?, de sorte que le rapport k¿cat?/k¿uncat? soit supérieur à 10.
Goudreau Gage Dubuc
Novartis International Pharmaceutical Ltd.
Research Corporation Technologies Inc.
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