Artificial cerebrospinal fluid

Details Artificial cerebrospinal fluid Artificial cerebrospinal fluid

A - Human Necessities

61

K

A61K 33/10 (2006.01) A61J 1/05 (2006.01) A61K 31/7016 (2006.01) A61K 33/14 (2006.01) A61P 7/10 (2006.01) A61P 19/00 (2006.01)

Patent

CA 2604454

An artificial cerebrospinal fluid comprising 120 to 160 mEq/L of a sodium ion, 1 to 6 mEq/L of a potassium ion, 75 to 155 mEq/L of a chlorine ion and 5 to 45 mEq/L of a bicarbonate ion; or an artificial cerebrospinal fluid further comprising at least one component selected from 10 g/L or less of a reducing sugar, 5 mmol/L or less of phosphoric acid, 5 mEq/L or less of a calcium ion and 5 mEq/L or less of a magnesium ion in addition to the components mentioned above. By using the artificial cerebrospinal fluid as a washing fluid or a perfusion fluid in the field of neurosurgery including intracranial surgery or a fluid replenisher for the lost cerebrospinal fluid, the development of cerebral edema can be prevented or reduced and a brain cell disorder can also be inhibited.

L'invention concerne un liquide céphalorachidien artificiel comprenant de 120 à 160 mEq/L d'ions de sodium, de 1 à 6 mEq/L d'ions de potassium, de 75 à 155 mEq/L d'ions de chlore et de 5 à 45 mEq/L d'ions de bicarbonate ou un liquide céphalorachidien artificiel comprenant en outre au moins un composant choisi parmi 10 g/L ou moins de sucre réduit, 5 mmole/L ou moins d'acide phosphorique, 5 mEq/L ou moins d'ions de calcium et 5 mEq/L ou moins d'ions de magnésium en plus des composants mentionnés ci-dessus. L~utilisation du liquide céphalorachidien artificiel comme liquide de lavage ou de perfusion dans le domaine de la neurochirurgie, y compris la chirurgie intracrânienne, ou comme apport liquide pour remplacer le liquide céphalorachidien perdu, permet de prévenir ou de réduire le développement d'un AEdème cérébral et d~inhiber un trouble des cellules cérébrales.

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