Artificial chromosomes, uses thereof and methods for...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/11 (2006.01) A01H 5/00 (2006.01) A01K 67/027 (2006.01) A01K 67/033 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C12N 15/62 (2006.01) C12N 15/64 (2006.01) C12N 15/82 (2006.01) C12N 15/85 (2006.01) C12N 15/90 (2006.01) C12P 1/00 (2006.01) C12P 21/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2250682

Methods for preparing cell lines that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, and methods for delivery of the chromosomes to selected cells and tissues are provided. Also provided are cell lines for use in the methods, and cell lines and chromosomes produced by the methods. In particular, satellite artificial chromosomes that, except for inserted heterologous DNA, are substantially composed of heterochromatin, are provided. Methods for use of the artificial chromosomes, including for gene therapy, production of gene products and production of transgenic plants and animals are also provided.

L'invention concerne des méthodes de préparation de lignées cellulaires qui contiennent des chromosomes artificiels, leurs procédés de préparation et de purification, des procédés d'insertion ciblée d'ADN hétérologue dans lesdits chromosomes artificiels et des procédés de libération desdits chromosomes dans des cellules et tissus sélectionnés. Elle porte aussi sur des lignées cellulaires à utiliser dans lesdits procédés, ainsi que sur des lignées cellulaires et des chromosomes produits selon lesdits procédés. On décrit, en particulier, des chromosomes artificiels satellites qui, à l'exception de l'ADN hétérologue inséré, se composent sensiblement d'hétérochromatine. Des procédés d'utilisation des chromosomes artificiels, dont la thérapie génique, la production de produits géniques et la production de plantes et d'animaux transgéniques sont également décrits.

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