C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/04 (2006.01) A61K 31/7084 (2006.01) A61K 31/7088 (2006.01) A61P 11/00 (2006.01) A61P 31/14 (2006.01)
Patent
CA 2533434
The present invention provides a series of artificial CpG-containing single- stranded oligodeoxynucleotides (ODNs), each of which is consisted of single-stranded oligodeoxynucleotide DNA molecule containing one or more CpG(s), wherein said ODNs can stimulate human peripheral blood mononuclear cell (PBMC) to produce antiviral substances. These ODNs can protect the cells against the attack from virus, wherein said virus is preferably selected from the group consisted of influenza virus and single-stranded positive strand RNA virus such as SARS virus, hepatitis C virus, dengue virus and Japanese encephalitis virus. Moreover, the antiviral use of artificial CpG ODNs and its use for treating and preventing viral infection are also provided.
La présente invention concerne un ensemble d'oligodésoxyribonucléotides (ODN) artificiels qui contiennent un ou plusieurs CpG, lesdits ODN pouvant stimuler les PBMC pour produire des substances antivirales. Ces substances antivirales rendent les cellules insensibles à l'attaque des virus, préférablement le virus de la grippe et le virus ARN plus à simple brin, tel que le virus de l'hépatite C, le virus de la dengue et le virus de l'encéphalite japonaise. La présente invention se rapporte également aux utilisations antivirales des ODN CpG artificiels et à leurs utilisations pour traiter et prévenir les infections virales.
Wang Liying
Yu Yongli
Changchun Huapu Biotechnology Co. Ltd.
Gowling Lafleur Henderson Llp
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