Artificial immune system: methods for making and use

Details Artificial immune system: methods for making and use Artificial immune system: methods for making and use

C - Chemistry, Metallurgy

12

N

C12N 5/078 (2010.01) C12N 5/071 (2010.01) A61K 35/12 (2006.01) A61K 35/14 (2006.01) A61K 35/26 (2006.01) A61K 39/00 (2006.01) C12M 3/00 (2006.01) C12N 11/00 (2006.01) C12N 11/02 (2006.01) C12P 1/00 (2006.01) C12P 21/00 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2564512

The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system.

La présente invention concerne des procédés de création d'un système immunitaire artificiel intégré comprenant des constructions tissulaires et cellulaires <i>in vitro </i> appropriées ou leurs équivalents pour imiter les tissus normaux qui interagissent avec les vaccins chez les mammifères. Ce système immunitaire artificiel peut être utilisé pour tester l'efficacité des candidats vaccins <i>in vitro </i> et est ainsi utile pour accélérer le développement des vaccins et tester l'interaction chimique et médicamenteuse avec le système immunitaire.

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