Artificial kidney having function of metabolizing protein...

A - Human Necessities – 61 – L

Patent

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Details

A61L 27/54 (2006.01) A61L 27/38 (2006.01) A61L 27/52 (2006.01) A61M 1/14 (2006.01) A61L 27/22 (2006.01)

Patent

CA 2445785

It is intended to provide an artificial kidney of intra-corporeal type which has a function of metabolizing protein. Namely, an artificial kidney of intra- corporeal type which has a function of metabolizing protein characterized by having as constituting members a sponge sheet having a hydrogel ontaining a growth factor, which promotes angiogenesis, injected thereinto and cells having megalin, which is an endocytosis receptor playing a major role in protein metabolism in proximal convoluted tubular cells, expressed on the surface; and a method of constructing an artificial kidney of intra-corporeal type which has a function of metabolizing protein characterized by using a sponge sheet having a hydrogen containing a growth factor, which promotes angiogenesis, injected thereinto and cells having megalin expressed on the surface.

L'invention concerne un rein artificiel de type intra-corporel, présentant une fonction de métabolisme de protéine. En particulier, le rein artificiel de type intra-corporel présentant une fonction de métabolisme de protéine est caractérisé en ce qu'il est formé d'éléments constitutifs formant une plaque d'éponge dans laquelle on a injecté un hydrogène présentant un facteur de croissance favorisant l'angiogénèse, et des cellules comportant de la mégaline, récepteur d'endocytose jouant un rôle majeur dans le métabolisme de protéine dans des cellules tubulaires convolutées proximales, exprimée en surface; et un procédé de fabrication d'un rein artificiel de type intra-corporel présentant une fonction de métabolisme de protéine, caractérisé en ce qu'il fait appel à une plaque d'éponge dans laquelle on a injecté un hydrogène présentant un facteur de croissance favorisant l'angiogénèse et des cellules comportant de la mégaline exprimée en surface.

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