Artificial liver apparatus and method

Details Artificial liver apparatus and method Artificial liver apparatus and method

A - Human Necessities

61

M

A61M 1/34 (2006.01)

Patent

CA 2201159

Artificial liver devices and methods for using the devices to purify a biological fluid are disclosed. The methods include the use of living hepatocytes (23) which are either unattached or attached to inert carriers and suspended in a cell culture medium which circulates in the devices with the hepatocytes (23). Blood or plasma passes on one side (7') of semi-permeable membranes, on the other side (7) of which is the cell culture medium and across which is a concentration and/or pressure gradient. Solutes diffusing across the membrane into the cell culture medium are metabolized by the hepatocytes (23) and/or captured by additional removal means (40). Those undesirable substances which do not diffuse out of the blood or plasma into the hepatocyte containing culture medium are captured by additional removal means (50).

Dispositifs constituant des foies artificiels permettant de purifier un fluide biologique et leur fonctionnement. Ce fonctionnement recouvre l'utilisation d'hépatocytes (23) vivants, fixés ou non à des porteurs inertes et en suspension dans un milieu de culture cellulaire s'écoulant avec les hépatocytes (23) dans ces dispositifs. Le sang ou le plasma passent d'un côté (7') de membranes semi-perméables, de l'autre côté (7) desquelles s'écoule un milieu de culture cellulaire et à travers lesquelles s'exerce un certain gradient de concentration et/ou de pression. Les solutés se diffusant à travers la membrane dans le milieu de culture cellulaire sont métabolisés par les hépatocytes (23) et/ou capturés par d'autres dispositifs complémentaires d'extraction (40). Les substances indésirables qui ne se diffusent pas hors du sang du plasma dans le milieu de culture contenant les hépatocytes sont capturées par des dispositifs complémentaires d'élimination (50).

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