A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 9/127 (2006.01) A61K 31/65 (2006.01) A61K 31/704 (2006.01) A61K 47/28 (2006.01) A61K 47/42 (2006.01)
Patent
CA 2507762
This invention relates to a highly efficient artificial low-density lipoprotein (LDL) carrier system for the targeted delivery therapeutic agents across the blood-brain barrier (BBB). In particular, this invention relates to artificial LDL particules comprised of three lipid elements: phosphatidyl choline, fatty-acyl-cholesterol esters, and at least one apolipoprotein. The present invention further relates to compositions, methods and kits comprising artificial LDL particules for targeting drugs to and across the BBB for the prevention and treatment of brain diseases. Moreover the present invention is directed to a conjugate formed by ester linkage between cholesterol and a therapeutic agent.
Cette invention se rapporte à un système porteur artificiel à base de lipoprotéines basse densité (LDL) artificielles, hautement efficace, pour le transport ciblé d'agents thérapeutiques à travers la barrière hémato-encéphalique (BBB). Cette invention se rapporte en particulier à des particules LDL artificielles constituées par trois éléments lipidiques : la phosphatidyl-choline, les esters de cholestérol d'acyle gras, et au moins une apolipoprotéine. Cette invention se rapporte en outre à des compositions, à des procédés et des kits comprenant des particules LDL artificielles pour le ciblage de médicaments vers et à travers la barrière hémato-encéphalique en vue de la prévention et du traitement de maladies cérébrales.
Alkon Daniel L.
Nelson Thomas J.
Quattrone Alessandro
Blanchette Rockefeller Neurosciences Institute
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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