Artificial pancreatic perfusion device with temperature...

Details Artificial pancreatic perfusion device with temperature... Artificial pancreatic perfusion device with temperature...

C - Chemistry, Metallurgy

12

N

C12N 5/08 (2006.01) A61F 2/02 (2006.01) A61K 35/39 (2006.01) A61M 1/34 (2006.01)

Patent

CA 2107123

2107123 9216165 PCTABS00016 A device which serves as an artificial pancreas comprises a hollow fiber (12) which is surrounded by islets of Langerhans (14) enclosed in a housing (22). The islets are suspended in a temperature sensitive matrix (25) which is sufficiently viscous to support islets at a temperature below about 45 ·C and sufficiently fluid to enable removal of islet suspension at a temperature above about 45 ·C. A warm (e.g., 48· to 50 ·C) solution may be flushed through the device to change the physical state of the temperature sensitive matrix from a semi-solid state to a liquified semi-gel state. The temperature sensitive supporting material also enables long term maintenance of islet cells in in vitro culture.

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