Artificial synapse chip interface for electronic prosthetic...

C - Chemistry – Metallurgy – 12 – M

Patent

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Details

C12M 3/00 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2451580

The invention provides microfabricated devices and methods for directing the growth of a cell process to form an artificial synapse. The devices are called artificial synapse chips. The artificial synapse comprises a nanofabricated aperture (about 50-100 nm in size) that connects the cell process to a chemical or electrical means of neuronal excitation. Such an aperture width mimics the length scales of a natural synapse and thus emphasizes the localized spatial relationship between a neuron and a stimulation source. The invention further provides devices and methods for regenerating a nerve fiber into an electrode. The invention thus provides a regeneration electrode that uses a novel neural interface for stimulation and that uses novel surface methods for directing neuronal growth making possible in vivo connection of the devices to neural circuitry in a retina and other anatomical locations.

La présente invention concerne des dispositifs micro-fabriqués et des procédés permettant d'orienter la croissance d'un processus cellulaire en vue de former une synapse artificielle. On appelle ces dispositifs des puces synaptiques artificielles. La synapse artificielle comporte un évidement de fabrication nanométrique (environ 100 nm de taille) reliant le processus cellulaire à des moyens chimiques ou électrique d'excitation neurale. Une telle largeur d'évidement est analogue aux échelles de longueur d'une synapse naturelle et donc intensifie la relation spatiale localisée entre un neurone et une source de stimulation. L'invention concerne également des dispositifs et des procédés permettant la régénération d'une fibre nerveuse en une électrode. Ainsi l'invention fournit une électrode de régénération qui utilise une nouvelle interface neurale pour la stimulation et qui utilise de nouveaux procédés de surface permettant l'orientation la croissance neurale rendant possible la connexion in vivo des dispositifs aux circuits neuraux dans la rétine et d'autres sites anatomiques.

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