Artificial tissue systems and uses thereof

A - Human Necessities – 61 – F

Patent

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Details

A61F 2/02 (2006.01) A61F 2/06 (2006.01) C12N 5/00 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2544726

An implant system and a method for controlling the natural and artificial microenvironments surrounding an implanted device using an artificial tissue system (ATS) and includes methods of diagnostic and testing related thereto. The ATS, among other things, induce better integration, function, and extended lifespan of the devices at the site of implantation. The ATS includes cells, such as naturally occurring, engineered, and/or artificial cells; matrices such as natural, engineered, artificial and/or hybrid matrices; tissue response modifiers (TRM); and/or cell response modifiers (CRM). The specific composition of the ATS is based on the nature of the tissue in which ATS- device combination is implanted and the nature of the implant device, as well as the required function and lifespan of the implanted device. Additionally, the ATS, as well as ATS~device combinations can be utilized in vitro to aid in the design of improved ATS, devices and ATS-device combinations for in vivo uses.

Un système d'implantation et un procédé de commande des micro-environnements naturels et artificiels entourant un dispositif implanté utilisant un système de tissus artificiels STA ainsi que des procédés diagnostiques et de mise à l'essai associés font l'objet de cette invention. Le STA, entre autres, induit l'intégration, entraîne une meilleure intégration, fonction et une durée de vie étendue des dispositifs au niveau du site d'implantation. Le STA comprend des cellules, notamment des cellules naturelles, génétiquement modifiées et/ou artificielles, des matrices, notamment des matrices naturelles, génétiquement modifiées, artificielles et/ou hybrides; des modificateurs de la réponse tissulaire MRT; et/ou des modificateurs de la réponse cellulaire MRC. La composition spécifique du STA est fondée sur la nature du tissu dans lequel la combinaison STA-dispositif est implantée et sur la nature du dispositif d'implantation, ainsi que sur la fonction requise et la durée de vie nécessaire du dispositif implanté. Par ailleurs, le STA, ainsi que les combinaisons STA-dispositif peuvent servir in vitro à la conception du STA amélioré, de dispositifs et de combinaisons de STA-dispositif en vue d'application in vivo.

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