Artificial transcriptional factors and methods of use

Details Artificial transcriptional factors and methods of use Artificial transcriptional factors and methods of use

C - Chemistry, Metallurgy

12

N

C12N 15/63 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2425917

An artificial transcription factors (ATF) is provided having a non-peptidic- DNA binding domain, flexible linker and a short synthetic effector domain. The ATFs are highly potent transcriptional modulators in vitro and in vivo. Methods for targeted manipulation of gene expression and the development of new class of pharmaceuticals are also provided.

L'invention concerne des facteurs transcriptionnels artificiels (ATF) possédant un domaine de liaison d'ADN non peptidique, un liant souple, et un domaine effecteur synthétique court. Les ATF sont des modulateurs transcriptionnels hautement efficaces <i>in vitro</i> et <i>in vivo</i>. L'invention concerne également des méthodes permettant d'effectuer une manipulation d'expression génique ciblée et de développer une nouvelle classe de substances pharmaceutiques.

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