Aryl, alkyl, alkenyl, and alkynylmacrolides

Details Aryl, alkyl, alkenyl, and alkynylmacrolides Aryl, alkyl, alkenyl, and alkynylmacrolides

C - Chemistry, Metallurgy

07

H

C07H 19/01 (2006.01) A61K 31/70 (2006.01) C07D 498/18 (2006.01)

Patent

CA 2192338

Aryl, alkyl, alkenyl and alkynyl macrolides of general structural Formula (I) have been prepared from suitable precursors by modification at C-30, C-33, and/or C-34 of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants and or related afflictions, diseases and illnesses.

Cette invention se rapporte à des macrolides aryles, akyles, alcényles et alcynyles, représentés par la formule développée générale (I), ces macrolides ayant été préparés à partir de précurseurs appropriés par modification en C-30, C-33 et/ou C-34 de la chaîne cyclohexyle. Ces macrolides immunosuppresseurs sont utiles dans l'organisme hôte d'un mammifère pour traiter les maladies auto-immunes et les maladies infectieuses et/ou pour prévenir le rejet de greffes d'organes étrangers et/ou les affections, maladies et maux apparentés.

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