Aryl-amino substituted pyrrolopyrimidine multi-kinase...

Details Aryl-amino substituted pyrrolopyrimidine multi-kinase... Aryl-amino substituted pyrrolopyrimidine multi-kinase...

C - Chemistry, Metallurgy

07

D

C07D 295/185 (2006.01) A61K 31/437 (2006.01) A61K 31/519 (2006.01) A61K 31/5355 (2006.01) A61K 31/541 (2006.01) A61K 31/55 (2006.01) A61K 31/5513 (2006.01) C07D 223/04 (2006.01) C07D 295/02 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2575808

Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mekl, PDK-1, GSK3~, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-lR, Ron, Ret, and KDR kinases in animals, including humans, for the treatment and/or prevention of various diseases and conditions such as cancer.

La présente invention a trait à des composés de formule (I), ou leurs stéréoisomères ou sels pharmaceutiquement acceptables, inhibiteurs d'au moins deux parmi les kinases Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mekl, PDK-1, GSK3ß, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-lR, Ron, Ret, et KDR chez des animaux, comprenant les humains, pour le traitement et/ou la prévention de diverses maladies et conditions telles que le cancer.

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