Aryl and biaryl compounds having mch modulatory activity

Details Aryl and biaryl compounds having mch modulatory activity Aryl and biaryl compounds having mch modulatory activity

C - Chemistry, Metallurgy

07

C

C07C 275/40 (2006.01) A61K 31/17 (2006.01) A61K 31/18 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) C07C 233/78 (2006.01) C07C 237/20 (2006.01) C07C 255/58 (2006.01) C07C 255/60 (2006.01) C07C 271/54 (2006.01) C07C 275/28 (2006.01) C07C 275/30 (2006.01) C07C 275/32 (2006.01) C07C 311/06 (2006.01) C07C 311/07 (2006.01) C07C 311/08 (2006.01) C07C 311/18 (2006.01) C07C 311/19 (2006.01) C07D 207/08 (2006.01) C07D 207/12 (2006.01) C07D 207/14 (2006.01) C07D 209/16 (2006.01) C07D 211/58 (2006.01) C07D 213/40

Patent

CA 2441235

In one embodiment, this invention provides a novel class of compounds as antagonists of the MCH receptor, methods of preparing such compounds, pharmaceutical compositions containing one or more of the compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention or amelioration or one or more of diseases associated with the MCH receptor. An illustrative inventive compound is shown here.

Dans un mode de réalisation, cette invention concerne une nouvelle classe de composés en tant qu'agonistes du récepteur de la MCH (hormone concentrant la mélanine), des méthodes de préparation de ces composés, des compositions pharmaceutiques contenant un ou plusieurs des composés, des méthodes de préparation de formulations pharmaceutiques contenant un ou plusieurs de ces composés, ainsi que des méthodes de traitement, de prévention ou d'amélioration d'une ou de plusieurs maladies associées au récepteur de MCH. Une illustration du composé de l'invention est représentée par la formule (I).

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