Aryl and biaryl piperidines used as mch antagonists

Details Aryl and biaryl piperidines used as mch antagonists Aryl and biaryl piperidines used as mch antagonists

C - Chemistry, Metallurgy

07

D

C07D 471/10 (2006.01) A61K 31/451 (2006.01) A61P 3/04 (2006.01) A61P 43/00 (2006.01) C07D 211/26 (2006.01) C07D 401/10 (2006.01) C07D 405/04 (2006.01) C07D 405/10 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2443672

In one embodiment, this invention provides a novel class (I) of compounds as antagonists of the MCH receptor, methods of preparing such compounds, pharmaceutical compositions containing one or more of the compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention or amelioration or one or more of diseases associated with the MCH receptor wherein Ar1 is selected from the following moieties (II). All substituents are as defined in the claims.

L'invention concerne, selon un mode de réalisation, une nouvelle catégorie (I) de composés utilisés en tant qu'antagonistes du récepteur de la MCH, des procédés de préparation desdits composés, des compositions pharmaceutiques contenant au moins un de ces composés, des procédés d'élaboration de préparations pharmaceutiques contenant au moins un de ces composés, ainsi que des méthodes permettant de traiter, prévenir ou atténuer au moins une maladie associée au récepteur de la MCH. Dans cette catégorie de composés, Ar?1¿ est choisi parmi les fractions suivantes: (II). Les substituants sont tels que définis dans les revendications.

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