C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 271/20 (2006.01) A61K 31/166 (2006.01) C07C 233/29 (2006.01) C07C 233/87 (2006.01) C07C 235/42 (2006.01) C07C 235/52 (2006.01) C07C 235/60 (2006.01) C07C 235/66 (2006.01) C07D 207/09 (2006.01) C07D 207/26 (2006.01) C07D 211/66 (2006.01) C07D 213/71 (2006.01) C07D 217/02 (2006.01) C07D 231/14 (2006.01)
Patent
CA 2531796
This invention provides aryl and heteroaryl compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention may be antagonists, or partial antagonist of factor IX and/or factor XI and thus, may be useful for inhibiting the intrinsic pathway of blood coagulation. The compounds may be useful in a variety of applications including the management, treatment and/or control of diseases caused in part by the intrinsic clotting pathway..
La présente invention concerne des composés aryle et hétéroaryle, des procédés pour les préparer, des compositions pharmaceutiques comprenant ces composés, et leur utilisation pour traiter des troubles chez les êtres humains et chez les animaux. Les composés de l'invention peuvent être des antagonistes ou antagonistes partiels du facteur IX et/ou facteur XI et peuvent ainsi être utiles pour inhiber le passage intrinsèque de la coagulation sanguine. Les composés peuvent être utilisés dans différentes applications comprenant la gestion, le traitement et/ou la régulation de maladies causées en partie par le passage de coagulation intrinsèque.
Andrews Robert C.
Behme Christopher
Christen Daniel Peter
Gohimmukkula Devi Reddy
Guo Xiao-Chuan
Moffat & Co.
Transtech Pharma Inc.
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