Aryl and heteroaryl fused aminoalkyl-imidazole...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 235/14 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 221/00 (2006.01) C07D 235/00 (2006.01) C07D 401/06 (2006.01) C07D 403/10 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2369544

Disclosed are compounds of formula (I) or pharmaceutically acceptable salts thereof wherein: R1 is not 3-fluorobenzyl and represents (C2-C6) alkenyl, aryl (C1-C6)alkyl or heteroaryl (C1-C6)alkyl, OR7, O(CH2)nC(O)R7, O(CH2)nNR7R8, O(CH2)nCO2R7, NR7COR8, COR7, CONR7R8 or CO2R7; R2 represents hydrogen, hydroxy, halogen, trifluoromethyl, trifluoromethoxy, amino (C1-C6)alkyl, mono- or di(C1-C6)alkylamino (C1-C6), or mono- or di(C1-C6)alkylamino(C1-C6)alkoxy; or OR7, O(CH2)nC(O)R7, O(CH2)nNR7R8, O(CH2)nCO2R7, NR7COR8, COR7, CONR7R8 or CO2R7; R3 represents (C1-C6)alkyl; R4 represents halogen or trifluoromethyl; R5 and R6 represent hydrogen, trifluoromethyl, triluoromethoxy, cyano, (C1- C6)alkyl, halogen, (C1-C6)alkylamino(C1-C6)alkyl, mono or di(C1- C6)alkylamino(C1-C6), or mono- or di(C1-C6)alkylamino(C1-C6)alkoxy; or together form a 5 or 6 membered aromatic ring which is optionally substituted. X represents a bond or CH2 which is optionally mono- or disubstituted with a (C1-C6)alkyl or (C1-C6)alkoxy; and A, B, C and D are the same or different and represent CRp or N with the proviso that not more than two of A,B, C and D represent N; which compounds are selective modulators of Bradykinin B2 receptors.

la présente invention concerne des composés de formule (I) ou des sels non toxiques pharmaceutiquement acceptables de ceux-ci. Dans cette formule A, B, C, et D sont N or CH; X est une liaison ou CH¿2? substitué ou non substitué; R¿1? est alcényle inférieur ou alkyle inférieur éventuellement substitué; R¿1? est alkyle inférieur; et R¿2?, R¿4?, R¿5?, et R¿6? sont des variables définies. Ces composés conviennent pour le diagnostic et le traitement de maladies rénales, pour des dysfonctionnements cardiaques, l'hypertension, la maladie de Ménière, les douleurs et les inflammations vaginales, les troubles de la circulation périphérique, les troubles climatériques, les troubles de la circulations rétinochoroïdienne, l'ischémie myocardique, l'infarctus du myocarde, le syndrome de Dressler, l'angine de poitrine, la resténose suite à angioplastie transluminale coronaire percutanée, l'hépatite, la cirrhose du foie, la pancréatite, les occlusions intestinales, le diabète, les complications diabétiques, l'infertilité masculine ou le glaucome, ou pour augmenter la perméabilité de la barrière hémato-encéphalique, pour les douleurs, l'asthme et les rhinites..

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