Aryl and heteroaryl fused aminoalkyl-imidazole derivatives:...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/04 (2006.01) A61K 31/4184 (2006.01) A61K 31/437 (2006.01) A61P 25/00 (2006.01) C07D 221/00 (2006.01) C07D 235/00 (2006.01) C07D 235/14 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2369557

Disclosed are compounds of formula (I), or the pharmaceutically acceptable non- toxic salts thereof wherein the A, B, C, D, X, R1, R2, R3, R4, R5, and R6, are variables defined herein, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors, and are therefore useful in the diagnosis and treatment of anxiety, Down Syndrome, sleep, cognitive and seizure disorders, depression, overdose with benzodiazepine drugs, and enhancement of memory and alertness.

La présente invention concerne des composés représentés par la formule (I) ou des sels non toxiques pharmaceutiquement acceptables de ceux-ci. Dans cette formule A, B, C, D, X, R¿1?, R¿2?, R¿3?, R¿4?, R¿5? et R¿6? sont des variables définies. Ces composés sont des agonistes hautement sélectifs, des antagonistes ou des agonistes inverses pour des récepteurs du cerveau GABAa ou des promédicaments d'agonistes, d'antagonistes ou d'agonistes inverses pour des récepteurs du cerveau GABAa, et ils conviennent par conséquent au diagnostic et au traitement de l'anxiété, du syndrome down, au traitement du sommeil, des troubles cognitifs et épileptiques, de la dépression, des overdoses aux médicaments à base de benzodiazepine, et ils renforcent la mémoire et la vivacité d'esprit.

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