Aryl and heteroaryl (phosphinylmethyl) phosphonate squalene...

Details Aryl and heteroaryl (phosphinylmethyl) phosphonate squalene... Aryl and heteroaryl (phosphinylmethyl) phosphonate squalene...

C - Chemistry, Metallurgy

07

F

C07F 9/38 (2006.01) A61K 31/66 (2006.01) C07F 9/40 (2006.01) C07F 9/547 (2006.01)

Patent

CA 2095279

HX60 ABSTRACT ARYL AND HETEROARYL(PHOSPHINYLMETHYL)PHOSPHONATE SOUALENE SYNTHETASE INHIBITORS AND METHOD Phosphonic acid squalene synthetase inhibitors are provided which are effective in lowering serum cholesterol and have the formula Image wherein m is 0 to 3, n is 1 to 5, Y1 and Y2 are H or halogen, R2, R3 and R4 are H, metal ion, C1 to C8 alkyl, C3 to C12 alkenyl, or prodrug ester, and R1 is a substituted or unsubstituted heteroaryl group or a substituted phenyl group.

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