Aryl and heteroaryl-piperidinecarboxylate derivatives, the...

Details Aryl and heteroaryl-piperidinecarboxylate derivatives, the... Aryl and heteroaryl-piperidinecarboxylate derivatives, the...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4523 (2006.01) C07D 211/36 (2006.01) C07D 211/52 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2554610

The invention relates to compounds of general formula (I), wherein m, n = 1 to 3 and m + n = 2 to 5 p = 1 A 7; A= single bond or X, Y and/or Z; X = methylene possibly substituted; Y = C¿2?-alkenylene possibly substituted or C¿2?-alkynylene; Z = C¿3-7?-cycloalkyl; R¿1? is an aryl or heteroaryl group; R¿2? is a hydrogen or fluoride atom, a hydroxyl, C¿1-6?-alkoxy or NR¿8?R¿9? group; R¿3? is a hydrogen atom or a C¿1- 6?-alkyl group; R¿4? is a hydrogen atom or a C¿1-6?-alkyl, C¿3-7?-cycloalkyl, C¿3-7?-cycloalkyl-C¿1-3?-alkyl group. Said compounds can be embodied in the form of a base, an acid addition salt, a hydrate or a solvate and can be used in the form of FAAH enzyme inhibitors.

Composé répondant à la formule générale (I): Les composés de l'invention répondent à la formule générale (I): dans laquelle m, n = 1 à 3 et m + n = 2 à 5 ; p = 1 à 7 ;A= liaison simple ou X, Y et/ou Z ; X = méthylène éventuellement substitué; Y = C2-alcènylène éventuellement substitué ou C2~alcynylène ; Z = C3-7-cycloalkyle ; R1 représente un groupe de type aryle ou hétéroaryle ; R2 représente un atome d'hydrogène ou de fluor, un groupe hydroxyle, C1-6-alcoxy ou NR8R9 ; R3 représente un atome d'hydrogène ou un groupe C1- 6-alkyle ; R4 représente un atome d'hydrogène ou un groupe C1-6- alkyle, C3-7-~cycloalkyle, C3-7-cycloalkyl-C1-3-alkyle; à l'état de base, de sel d'addition à un acide, d'hydrate ou de solvat. Ces composés sont utilisés comme inhibiteurs de l'enzyme FAAH.

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