Aryl- and heteroaryl-substituted tetrahydroisoquinolines and...

Details Aryl- and heteroaryl-substituted tetrahydroisoquinolines and... Aryl- and heteroaryl-substituted tetrahydroisoquinolines and...

C - Chemistry, Metallurgy

07

D

C07D 217/04 (2006.01) A61K 31/472 (2006.01) A61K 31/4725 (2006.01) A61P 25/00 (2006.01) C07D 401/04 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2389306

Provided herein are compounds of formula (I), wherein R1-R8 are as described herein, R4 being aryl or heteroaryl. Such compounds are particularly use-ful in the treatment of a disorder which is created by or is dependent upon decreased availability of serotonin, norepinephrine or dopamine.

L'invention concerne des composés de la formule (I) dans laquelle R?1¿-R?8¿ ont la signification donnée dans le descriptif, R?4¿ étant de l'aryle, ou de l'hétéroaryle. De tels composés sont particulièrement utiles dans le traitement d'un dysfonctionnement provoqué par ou dépandant d'une diminution de la disponibilité de sérotonine, de norepinéphrine, ou de dopamine.

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