Aryl- and heteroarylcarbonyl derivatives of substituted...

Details Aryl- and heteroarylcarbonyl derivatives of substituted... Aryl- and heteroarylcarbonyl derivatives of substituted...

C - Chemistry, Metallurgy

07

D

C07D 451/02 (2006.01) A61K 31/46 (2006.01) A61P 3/00 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2735204

The present invention relates to compounds defined by formula (I) wherein the groups R1 and R2 are defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11.beta.-hydroxysteroid dehydro-genase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this en-zyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.

La présente invention concerne des composés définis par la formule (I) où les groupements R1 et R2 sont tels que définis dans la revendication 1, et présentant une activité pharmacologique intéressante. En particulier, les composés sont des inhibiteurs de la 11-ß-hydroxystéroïde déshydrogénase (HSD) 1 et sont donc adaptés au traitement prophylactique et thérapeutique de pathologies pouvant être influencées par l'inhibition de cette enzyme, comme les maladies métaboliques, en particulier le diabète de type 2, l'obésité et la dyslipidémie.

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