Aryl, aryloxy, and alkyloxy substituted 1h-indol-3-yl...

Details Aryl, aryloxy, and alkyloxy substituted 1h-indol-3-yl... Aryl, aryloxy, and alkyloxy substituted 1h-indol-3-yl...

C - Chemistry, Metallurgy

07

D

C07D 209/12 (2006.01) A61K 31/405 (2006.01) A61K 31/433 (2006.01) A61K 31/4439 (2006.01) C07D 209/18 (2006.01) C07D 209/22 (2006.01) C07D 209/24 (2006.01) C07D 401/12 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2509191

Compounds of formula (I) are provided: wherein R1, R2 and R3, are as defined herein, as well ad pharmaceutical composition and methods using the compounds as inhibitors of plasminogen activator inhibitor (PAI-1) and as therapeutic composition for treating conditions resulting from fibrinolytic disorders, such as deep vein thrombosis, coronary heart disease and pulmonary fibrosis.

L'invention concerne des composés de formule (I) dans laquelle R¿1?, R¿2? et R¿3?, sont tels que définis dans la description, ainsi qu'une composition pharmaceutique et des méthodes faisant appel auxdits composés en tant qu'inhibiteurs de l'inhibiteur de l'activateur du plasminogène (PAI-1) et en tant que composition thérapeutique pour traiter des états pathologiques liés à des troubles fibrinolytiques, tels que les thromboses veineuses profondes, les maladies coronariennes et les fibroses pulmonaires.

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