C - Chemistry – Metallurgy – 08 – F
Patent
C - Chemistry, Metallurgy
08
F
C08F 20/60 (2006.01) A61K 31/80 (2006.01) A61P 3/04 (2006.01) C08B 37/00 (2006.01) C08F 16/06 (2006.01) C08G 73/02 (2006.01)
Patent
CA 2487857
Disclosed are polymers comprising one or more phenyl boronate ester, boronamide or boronate thioester groups. The phenyl boronate ester, boronamide and boronate thioester groups are represented by one of the following structural formulas: Ar in Structural Formulas (I) and (II) is substituted or unsubstituted; and each Z is O-, NH-or -S- and is independently selected. Pharmaceutically acceptable salts of the polymer are also included. The arly boronate ester, boronamide or boronate thioester can be cleaved to release the corresponding aryl boronic acid. Also disclosed are pharmaceutical compositions comprising the polymers of the present invention and a pharmaceutically acceptable carrier or diluent; and methods of treating a subject for obesity with the polymers of the present invention.
L'invention concerne des polymères comprenant un ou plusieurs groupes ester phénylboronate, boronamide ou thioester boronate. Les groupes ester phénylboronate, boronamide et thioester boronate sont représentés par l'une des formules structurales suivantes: Ar dans les formules structurales (I) et (II) est substitué ou non, et chaque Z représente O-, NH- ou -S- et est choisi de manière indépendante. L'invention concerne aussi des sels de ces polymères, acceptables sur le plan pharmaceutique. Le groupe ester arylboronate, boronamide ou thioester boronate peut être clivé afin de libérer l'acide arylboronique correspondant. L'invention concerne aussi des compositions pharmaceutiques comprenant ces polymères et un support ou un diluant, acceptable sur le plan pharmaceutique, ainsi que des méthodes de traitement d'un sujet avec les polymères de cette invention.
Dhal Pradeep K.
Holmes-Farley Stephen Randall
Huval Chad Cori
Li Xinhua
Mandeville Harry W. III
Borden Ladner Gervais Llp
Genzyme Corporation
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